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The California floristic province is home to more than 30% of all Castilleja species across the North American wildflower genus (family Orobanchaceae). While some of the approximately 200 species are distinct morphologically, the five species composing the coastal California Castilleja species complex exhibit overlapping morphologies and geographic ranges, which poses particular challenges for species identification. To determine species, current keys employ a combination of geography, leaves, and reproductive structures. The sepals, known collectively as the calyx, are modified leaves that protect the flower and have historically been one of several important traits for diagnosing species in the complex. In this project, we utilized geometric morphometrics to quantify and describe calyx shape for three calyces per individual of five individuals across seven species, including two outgroups (n = 84). While traditional morphometrics only capture linear variation, geometric morphometrics translate more complex elements of shape. Calyx outlines were created from field scans and analyzed with Procrustes-based geometric morphometrics using three landmarks, followed by elliptic Fourier analysis. The first principal component axis across all samples explained 43.8% of variation and emphasized the depths of the calyx clefts relative to each other. Several species overlap in the morphospace while others remain distinct, which suggests limited morphological differentiation of the calyx across species and may allow for variation in successful pollination. Future analyses will quantify morphological variation in other floral organs observed both within individuals and within species to comprehensively assess morphological variation in the complex. 

In the discovery process of new drugs and the development of novel therapies in medicine, computational modeling is a complementary tool for the design of new molecules by predicting for example their solubility in different solvents. Here, we benchmarked several computational methods to calculate the partition coefficients of a diverse set of 161 organic molecules with experimental logP values obtained from the literature. In general, density functional theory methods yielded the best correlations and lower average deviations. Although results are obtained faster with semiempirical and molecular mechanics methodologies, these methods yielded higher average deviations and lower correlation coefficients than hybrid density functional theory methods. We recommend the use of an empirical formula to correct the calculated values with each methodology tested. 

Abstract Despite the f₀(980) hadron having been discovered half a century ago, the question about its quark content has not been settled: it might be an ordinary quark-antiquark ($${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$) meson, a tetraquark ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}q\overline{q}$) exotic state, a kaon-antikaon ($${{\rm{K}}}\overline{{{\rm{K}}}}$$ $K\overline{K}$) molecule, or a quark-antiquark-gluon ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{g}}}$$ $q\overline{q}g$) hybrid. This paper reports strong evidence that the f₀(980) state is an ordinary$${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$meson, inferred from the scaling of elliptic anisotropies (v₂) with the number of constituent quarks (n_q), as empirically established using conventional hadrons in relativistic heavy ion collisions. The f₀(980) state is reconstructed via its dominant decay channel f₀(980) →π⁺π⁻, in proton-lead collisions recorded by the CMS experiment at the LHC, and itsv₂is measured as a function of transverse momentum (p_T). It is found that then_q= 2 ($${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$state) hypothesis is favored overn_q= 4 ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}q\overline{q}$or$${{\rm{K}}}\overline{{{\rm{K}}}}$$ $K\overline{K}$states) by 7.7, 6.3, or 3.1 standard deviations in thep_T< 10, 8, or 6 GeV/cranges, respectively, and overn_q= 3 ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{g}}}$$ $q\overline{q}g$hybrid state) by 3.5 standard deviations in thep_T< 8 GeV/crange. This result represents the first determination of the quark content of the f₀(980) state, made possible by using a novel approach, and paves the way for similar studies of other exotic hadron candidates. 

Existing three-dimensional (3D) culture techniques are limited by trade-offs between throughput, capacity for high-resolution imaging in living state, and geometric control. Here, we introduce a modular microscale hanging drop culture where simple design elements allow high replicates for drug screening, direct on-chip real-time or high-resolution confocal microscopy, and geometric control in 3D. Thousands of spheroids can be formed on our microchip in a single step and without any selective pressure from specific matrices. Microchip cultures from human LN229 glioblastoma and patient-derived mouse xenograft cells retained genomic alterations of originating tumors based on mate pair sequencing. We measured response to drugs over time with real-time microscopy on-chip. Last, by engineering droplets to form predetermined geometric shapes, we were able to manipulate the geometry of cultured cell masses. These outcomes can enable broad applications in advancing personalized medicine for cancer and drug discovery, tissue engineering, and stem cell research. 

The ALICE Collaboration reports measurements of the large relative transverse momentum ( $k_T$) component of jet substructure in $pp$and Pb-Pb collisions at center-of-mass energy per nucleon pair $\sqrt{s_{\mathrm{NN}}}=5.02\mathrm{TeV}$. Enhancement in the yield of such large- $k_{\mathrm{T}}$emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma. The analysis utilizes charged-particle jets reconstructed by the anti- $k_{\mathrm{T}}$algorithm with resolution parameter $R=0.2$in the transverse-momentum interval $60<p_{\mathrm{T},\mathrm{ch},\mathrm{jet}}<80\mathrm{GeV}/c$. The soft drop and dynamical grooming algorithms are used to identify high transverse momentum splittings in the jet shower. Comparison of measurements in Pb-Pb and $pp$collisions shows medium-induced narrowing, corresponding to yield suppression of high- $k_T$splittings, in contrast to the expectation of yield enhancement due to quasiparticle scattering. The measurements are compared to theoretical model calculations incorporating jet modification due to jet-medium interactions (“jet quenching”), both with and without quasiparticle scattering effects. These measurements provide new insight into the underlying mechanisms and theoretical modeling of jet quenching. 

Abstract This paper presents a study of the inclusive forward J/ψyield as a function of forward charged-particle multiplicity in pp collisions at$$ \sqrt{s} $$ $\sqrt{s}$= 13 TeV using data collected by the ALICE experiment at the CERN LHC. The results are presented in terms of relativeJ/ψyields and relative charged-particle multiplicities with respect to these quantities obtained in inelastic collisions having at least one charged particle in the pseudorapidity range |η|<1. The J/ψmesons are reconstructed via their decay intoμ⁺μ⁻pairs in the forward rapidity region (2.5< y <4). The relative multiplicity is estimated in the forward pseudorapidity range which overlaps with the J/ψrapidity region. The results show a steeper-than-linear increase of the J/ψyields versus the multiplicity. They are compared with previous measurements and theoretical model calculations. 

Abstract Event-by-event fluctuations of the event-wise mean transverse momentum,$$\langle p_{\textrm{T}}\rangle $$ $⟨p_{\text{T}}⟩$, of charged particles produced in proton–proton (pp) collisions at$$\sqrt{s}$$ $\sqrt{s}$= 5.02 TeV, Xe–Xe collisions at$$\sqrt{s_{\textrm{NN}}}$$ $\sqrt{s_{\text{NN}}}$= 5.44 TeV, and Pb–Pb collisions at$$\sqrt{s_{\textrm{NN}}}$$ $\sqrt{s_{\text{NN}}}$= 5.02 TeV are studied using the ALICE detector based on the integral correlator$$\langle \!\langle \Delta p_\textrm{T}\Delta p_\textrm{T}\rangle \!\rangle $$ $⟨⟨\Delta p_{\text{T}}\Delta p_{\text{T}}⟩⟩$. The correlator strength is found to decrease monotonically with increasing produced charged-particle multiplicity measured at midrapidity in all three systems. In Xe–Xe and Pb–Pb collisions, the multiplicity dependence of the correlator deviates significantly from a simple power-law scaling as well as from the predictions of the HIJING and AMPT models. The observed deviation from power-law scaling is expected from transverse radial flow in semicentral to central Xe–Xe and Pb–Pb collisions. In pp collisions, the correlation strength is also studied by classifying the events based on the transverse spherocity,$$S_0$$ $S_0$, of the particle production at midrapidity, used as a proxy for the presence of a pronounced back-to-back jet topology. Low-spherocity (jetty) events feature a larger correlation strength than those with high spherocity (isotropic). The strength and multiplicity dependence of jetty and isotropic events are well reproduced by calculations with the PYTHIA 8 and EPOS LHC models. 

A<sc>bstract</sc> We report on the measurement of inclusive, non-prompt, and prompt J/ψ-hadron correlations by the ALICE Collaboration at the CERN Large Hadron Collider in pp collisions at a center-of-mass energy of 13 TeV. The correlations are studied at midrapidity (|y| <0.9) in the transverse momentum rangesp_T<40 GeV/cfor the J/ψand 0.15< p_T<10 GeV/cand |η|<0.9 for the associated hadrons. The measurement is based on minimum bias and high multiplicity data samples corresponding to integrated luminosities ofL_int= 34 nb⁻¹andL_int= 6.9 pb⁻¹, respectively. In addition, two more data samples are employed, requiring, on top of the minimum bias condition, a threshold on the tower energy ofE= 4 and 9 GeV in the ALICE electromagnetic calorimeters, which correspond to integrated luminosities ofL_int= 0.9 pb⁻¹andL_int= 8.4 pb⁻¹, respectively. The azimuthally integrated near and away side yields of associated charged hadrons per J/ψtrigger are presented as a function of the J/ψand associated hadron transverse momentum. The measurements are discussed in comparison to PYTHIA calculations.